The noncalciotropic actions of vitamin D: Recent clinical developments

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56 Scopus citations


Purpose of review This review summarizes recently described actions of 1,25-dihydroxyvitamin D beyond its function in calcium homeostasis and bone metabolism. Recent findings 1,25-Dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberculosis. Hypovitaminosis D has been associated with several autoimmune disorders, various malignancies, and cardiovascular risk factors in a number of recent epidemiologic reports. Based on these observational reports, vitamin D and its analogues are being evaluated for the prevention and treatment of a variety of conditions, with early findings showing mixed results. Summary The broad tissue distribution of the 25-hydroxyvitamin D 1a-hydroxylase enzyme and the vitamin D receptor establish a role for 1,25-dihydroxyvitamin D in the pathophysiology of various disease states and provide new therapeutic targets for vitamin D and its analogues.

Original languageEnglish (US)
Pages (from-to)408-415
Number of pages8
JournalCurrent opinion in nephrology and hypertension
Issue number4
StatePublished - Jul 2008


  • 25-Hydroxyvitamin D 1α-hydroxylase
  • Vitamin D
  • Vitamin D receptor

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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