@article{af8919a3b73f411c8edb0a8e43c755a8,
title = "The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory",
abstract = "Recent exome sequencing studies have implicated polymorphic Brg1-Associated Factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several human intellectual disabilities and cognitive disorders. However, it is currently unknown how mutations in BAF complexes result in impaired cognitive function. Postmitotic neurons express a neuron-specific assembly, nBAF, characterized by the neuron-specific subunit BAF53b. Mice harboring selective genetic manipulations of BAF53b have severe defects in long-term memory and long-lasting forms of hippocampal synaptic plasticity. We rescued memory impairments in BAF53b mutant mice by reintroducing BAF53b in the adult hippocampus, which suggests a role for BAF53b beyond neuronal development. The defects in BAF53b mutant mice appeared to derive from alterations in gene expression that produce abnormal postsynaptic components, such as spine structure and function, and ultimately lead to deficits in synaptic plasticity. Our results provide new insight into the role of dominant mutations in subunits of BAF complexes in human intellectual and cognitive disorders.",
author = "Annie Vogel-Ciernia and Matheos, {Dina P.} and Barrett, {Ruth M.} and Kram{\'a}r, {Enik{\"o} A.} and Soraya Azzawi and Yuncai Chen and Magnan, {Christophe N.} and Michael Zeller and Angelina Sylvain and Jakob Haettig and Yousheng Jia and Anthony Tran and Richard Dang and Post, {Rebecca J.} and Meredith Chabrier and Babayan, {Alex H.} and Wu, {Jiang I.} and Crabtree, {Gerald R.} and Pierre Baldi and Baram, {Tallie Z.} and Gary Lynch and Wood, {Marcelo A.}",
note = "Funding Information: We wish to acknowledge the University of California at Irvine Institute for Genomics and Bioinformatics and Genomics High-Throughput Facility, and J. Hayes for additional computing support. We would like to thank J. Guzowski and T. Miyashita for their technical expertise and the use of the BX61 microscope and XC10 camera. This work was supported by grants from the US National Institutes of Health (MH081004 and DA025922 to M.A.W., and training grant T32-AG00096-29 to A.V.C.). G.L., E.K. and Y.J. were supported by grants from the US National Institutes of Health (P01 NS045260) and ONR (#N00014-10-1-0072). T.Z.B. was supported by US National Institutes of Health grants NS 28912 and MH73136. The work of M.Z., C.M. and P.B. was supported by grants from the National Science Foundation (IIS-0513376), the US National Institutes of Health (LM010235) and the National Library of Medicine (T15 LM07443) to P.B.",
year = "2013",
month = may,
doi = "10.1038/nn.3359",
language = "English (US)",
volume = "16",
pages = "552--561",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "5",
}