The molecular basis for carcinogenesis in metaplastic columnar-lined esophagus

R. F. Souza, S. J. Meltzer

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Barrett's esophagus carries an increased risk for the development of esophageal adenocarcinoma. A wide variety of biologic events play a role in the initiation and progression of Barrett's esophagus to malignancy. Understanding Balrett's-associated neoplasia at the molecular level could generate markers predictive of malignant change. The next several years promise many discoveries of not only these molecular markers of tumorigenesis, but also their clinical application as means of preventing and treating the deadly complications of Barrett's esophagus.

Original languageEnglish (US)
Pages (from-to)583-597
Number of pages15
JournalGastroenterology Clinics of North America
Issue number3
StatePublished - 1997

ASJC Scopus subject areas

  • Gastroenterology


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