The mitogen-activated protein kinases, ERK1 and ERK2

Melanie H. Cobb, Jessie E. Hepler, Mangeng Cheng, David Robbins

Research output: Contribution to journalArticlepeer-review

139 Scopus citations


The MAP kinases are ubiquitous enzymes that are activated in a complex fashion and inactivated by multiple phosphatases including a dedicated dual specificity enzyme. These kinases have a diverse array of substrates with important functions that result in their substantial regulatory impact. The ERK/MAP kinase cascade displays not only downstream but also upstream interactions as well as cross talk with other signaling pathways which fine tunes the cascade in a cell type-specific fashion. Transforming agents utilize this cascade in inducing cell proliferation.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalSeminars in Cancer Biology
Issue number4
StatePublished - 1994


  • Extracellular signal-regulated kinase
  • MAP kinase

ASJC Scopus subject areas

  • Cancer Research


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