TY - JOUR
T1 - The microbial and host factors that govern Candida gastrointestinal colonization and dissemination
AU - Mishra, Animesh Anand
AU - Koh, Andrew Y.
N1 - Funding Information:
A.Y.K: the US National Institutes of Health (NIH) grant R01AI123163 , K24AI150992 .
Funding Information:
A.Y.K: Prolacta (consulting), Merck (sponsored research), Novartis (sponsored research).A.Y.K: the US National Institutes of Health (NIH) grant R01AI123163, K24AI150992.
Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Candida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of great interest. Here, we review the recent advances and insights regarding Candida colonization and dissemination of the mammalian GI tract.
AB - Candida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. The microbial and/or host factors that dictate CA's ability to colonize mucosal surfaces and its ability to disseminate remain of great interest. Here, we review the recent advances and insights regarding Candida colonization and dissemination of the mammalian GI tract.
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U2 - 10.1016/j.mib.2021.05.012
DO - 10.1016/j.mib.2021.05.012
M3 - Review article
C2 - 34111679
AN - SCOPUS:85107447270
SN - 1369-5274
VL - 63
SP - 29
EP - 35
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -