Abstract
The metabolic syndrome is a common metabolic disorder that results from the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) will be applicable worldwide. The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated. A proinflammatory state probably contributes to the syndrome. The increased risk for type 2 diabetes and cardiovascular disease demands therapeutic attention for those at high risk. The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction.
Original language | English (US) |
---|---|
Pages (from-to) | 1415-1428 |
Number of pages | 14 |
Journal | Lancet |
Volume | 365 |
Issue number | 9468 |
DOIs | |
State | Published - Apr 16 2005 |
ASJC Scopus subject areas
- General Medicine