The many ways to make a luminal cell and a prostate cancer cell

Douglas W. Strand, Andrew S. Goldstein

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Research in the area of stem/progenitor cells has led to the identification of multiple stemlike cell populations implicated in prostate homeostasis and cancer initiation. Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, our focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. In this article, we will review the literature, present the evidence and raise important unanswered questions that will help guide the field forward in dissecting critical mechanisms regulating stem-cell differentiation and tumor initiation.

Original languageEnglish (US)
Pages (from-to)T187-T197
JournalEndocrine-Related Cancer
Issue number6
StatePublished - Dec 2015


  • Carcinoma
  • Prostate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research


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