TY - JOUR
T1 - The LXRs
T2 - A new class of oxysterol receptors
AU - Peet, Daniel J.
AU - Janowski, Bethany A.
AU - Mangelsdorf, David J.
PY - 1998/10
Y1 - 1998/10
N2 - The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.
AB - The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.
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U2 - 10.1016/S0959-437X(98)80013-0
DO - 10.1016/S0959-437X(98)80013-0
M3 - Article
C2 - 9794827
AN - SCOPUS:0032191340
SN - 0959-437X
VL - 8
SP - 571
EP - 575
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -