TY - JOUR
T1 - The low density lipoprotein pathway in human fibroblasts
AU - Brown, Michael S.
AU - Goldstein, Joseph L.
PY - 1976/7
Y1 - 1976/7
N2 - Recent studies indicate that low density lipoprotein is ingested by human fibroblasts in a process kinetically similar to adsorptive endocytosis. Patients lacking the necessary cell surface receptor, Familial Hypercholesterolemia homozygotes, have a defective uptake of low density lipoprotein, consequently impaired regulation of cholesterol synthesis and develop hypercholesterolemia and fulminant atherosclerosis.
AB - Recent studies indicate that low density lipoprotein is ingested by human fibroblasts in a process kinetically similar to adsorptive endocytosis. Patients lacking the necessary cell surface receptor, Familial Hypercholesterolemia homozygotes, have a defective uptake of low density lipoprotein, consequently impaired regulation of cholesterol synthesis and develop hypercholesterolemia and fulminant atherosclerosis.
UR - http://www.scopus.com/inward/record.url?scp=0017035645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017035645&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(76)80027-8
DO - 10.1016/S0968-0004(76)80027-8
M3 - Review article
AN - SCOPUS:0017035645
SN - 0376-5067
VL - 1
SP - 193
EP - 195
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 3
ER -