The liver X receptor gene team: Potential new players in atherosclerosis

Joyce J. Repa; David J. Mangelsdorf

doi:10.1038/nm1102-1243

The liver X receptor gene team: Potential new players in atherosclerosis

Joyce J. Repa, David J. Mangelsdorf

Research output: Contribution to journal › Review article › peer-review

340 Scopus citations

Abstract

Liver X receptors (LXRs) are sterol-responsive transcription factors that regulates expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has imnplicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.

Original language	English (US)
Pages (from-to)	1243-1248
Number of pages	6
Journal	Nature medicine
Volume	8
Issue number	11
DOIs	https://doi.org/10.1038/nm1102-1243
State	Published - Nov 1 2002

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "The liver X receptor gene team: Potential new players in atherosclerosis",

abstract = "Liver X receptors (LXRs) are sterol-responsive transcription factors that regulates expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has imnplicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.",

author = "Repa, {Joyce J.} and Mangelsdorf, {David J.}",

note = "Funding Information: Acknowledgments Many primary references could not be included because of space limitations. D.J.M. is an investigator of the Howard Hughes Medical Institute. This work was supported by the Howard Hughes Medical Institute and the Robert A. Welch Foundation. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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N2 - Liver X receptors (LXRs) are sterol-responsive transcription factors that regulates expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has imnplicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.

AB - Liver X receptors (LXRs) are sterol-responsive transcription factors that regulates expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has imnplicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.

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The liver X receptor gene team: Potential new players in atherosclerosis

Abstract

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