The link between T helper balance and lymphoproliferative disease

Anthony J. Yun, Patrick Y. Lee

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Lymphoproliferative disorders comprise a heterogeneous group of neoplasms whose behaviors range from indolent to very aggressive. The increased incidence seen in the context of immunodeficiency provides evidence that the host immune system plays a vital role in their pathogenesis. We believe that T-helper (Th)-2 dominant states favor development of lymphoproliferative disorders, including lymphoma, and conversely T-helper (Th)-1 immunity protects against lymphoproliferative disease. The age distribution of lymphomas favors childhood and post-reproductive senescence, suggesting that exposure to these periods of Th-2 bias constitutes a key risk factor for developing the disease. The tendency of lymphomas to arise in Th-2 biased locations such as mucosal interfaces, immunoprivileged sites, and regions of B-cell differentiation may likewise reflect a corresponding spatial predilection. Various clinical conditions or treatments that shift Th1/Th2 balance, including HIV infection, transplant-related immune suppression, and autoimmune disorders, can also influence the status of lymphoproliferative diseases.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalMedical Hypotheses
Issue number3
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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