TY - JOUR
T1 - The level of plasma amyloid-β 40 is correlated with peripheral transport proteins in cognitively normal adults
T2 - A population-based cross-sectional study
AU - Gao, Ling
AU - Jiang, Yu
AU - Wei, Shan
AU - Shang, Suhang
AU - Li, Pei
AU - Chen, Chen
AU - Dang, Liangjun
AU - Wang, Jin
AU - Huo, Kang
AU - Deng, Meiying
AU - Wang, Jingyi
AU - Zhang, Rong
AU - Qu, Qiumin
N1 - Publisher Copyright:
© 2018 - IOS Press and the authors. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Background: Transport proteins, soluble low-density lipoprotein receptor-related protein-1 (sLRP1), and soluble receptor of advanced glycation end products (sRAGE), play an important role in the clearance of plasma amyloid-β (Aβ). However, their relationship is not clear. Objective: The aim was to explore the relationship between plasma levels of sLRP1, sRAGE, and Aβ in a cross-sectional study. Methods: A total of 1,185 cognitively normal participants (age above 40) from a village in the suburbs of Xi'an, China were enrolled from October 8, 2014 to March 30, 2015. Plasma Aβ 40, Aβ 42, sLRP1, and sRAGE were tested using a commercial ELISA. Apolipoprotein E (APOE) genotyping was conducted using PCR and sequencing. The relationship between plasma levels of sLRP1, sRAGE, and Aβ was analyzed using Pearson's correlation analysis and multiple linear regression. Results: In the total population, Log sLRP1 and Log sRAGE were positively correlated with plasma Aβ 40 (r= 0.103, p < 0.001; r= 0.064, p = 0.027, respectively), but neither were associated with plasma Aβ 42. After multivariable adjustment in the regression model, Log sLRP1 and Log sRAGE were still positively related with plasma Aβ 40 (β= 2.969, p < 0.001; β= 1.936, p = 0.017, respectively) but not Aβ 42. Furthermore, the positive correlations between transport proteins and plasma Aβ 40 remained significant only in APOE ϵ4 non-carriers after Pearson's analysis and multiple regression analysis after stratification by gene status. Conclusion: The concentrations of plasma sLRP1 and sRAGE had a significant impact on the level of plasma Aβ 40 in cognitively normal adults, especially in APOE ϵ4 non-carriers. However, the mechanism by which the transport proteins are involved in peripheral Aβ clearance and the relationship between transporters and amyloid burden in the brain needs further validation.
AB - Background: Transport proteins, soluble low-density lipoprotein receptor-related protein-1 (sLRP1), and soluble receptor of advanced glycation end products (sRAGE), play an important role in the clearance of plasma amyloid-β (Aβ). However, their relationship is not clear. Objective: The aim was to explore the relationship between plasma levels of sLRP1, sRAGE, and Aβ in a cross-sectional study. Methods: A total of 1,185 cognitively normal participants (age above 40) from a village in the suburbs of Xi'an, China were enrolled from October 8, 2014 to March 30, 2015. Plasma Aβ 40, Aβ 42, sLRP1, and sRAGE were tested using a commercial ELISA. Apolipoprotein E (APOE) genotyping was conducted using PCR and sequencing. The relationship between plasma levels of sLRP1, sRAGE, and Aβ was analyzed using Pearson's correlation analysis and multiple linear regression. Results: In the total population, Log sLRP1 and Log sRAGE were positively correlated with plasma Aβ 40 (r= 0.103, p < 0.001; r= 0.064, p = 0.027, respectively), but neither were associated with plasma Aβ 42. After multivariable adjustment in the regression model, Log sLRP1 and Log sRAGE were still positively related with plasma Aβ 40 (β= 2.969, p < 0.001; β= 1.936, p = 0.017, respectively) but not Aβ 42. Furthermore, the positive correlations between transport proteins and plasma Aβ 40 remained significant only in APOE ϵ4 non-carriers after Pearson's analysis and multiple regression analysis after stratification by gene status. Conclusion: The concentrations of plasma sLRP1 and sRAGE had a significant impact on the level of plasma Aβ 40 in cognitively normal adults, especially in APOE ϵ4 non-carriers. However, the mechanism by which the transport proteins are involved in peripheral Aβ clearance and the relationship between transporters and amyloid burden in the brain needs further validation.
KW - Alzheimer's disease
KW - amyloid-β
KW - soluble low-density lipoprotein receptor-related protein-1 (sLRP1)
KW - soluble receptor of advanced glycation end products (sRAGE)
KW - transport proteins
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U2 - 10.3233/JAD-180399
DO - 10.3233/JAD-180399
M3 - Article
C2 - 30103331
AN - SCOPUS:85053732666
SN - 1387-2877
VL - 65
SP - 951
EP - 961
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -