Abstract
The LDL-receptor-related protein is a multifunctional clearance receptor that removes remnant lipoproteins and proteases from the extracellular space. In the absence of functional receptors, mouse embryos fail early in development, probably as a result of a failure to clear protease/antiprotease complexes from the surface of the invading trophoblast. A receptor-associated protein blocks the binding of all ligands and appears to function as a rapid regulator of receptor activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-113 |
| Number of pages | 7 |
| Journal | Current opinion in lipidology |
| Volume | 4 |
| Issue number | 2 |
| State | Published - 1993 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Genetics
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
- Cell Biology