The LDL-receptor-related protein - Portrait of a multifunctional receptor

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85 Scopus citations


The LDL-receptor-related protein is a multifunctional clearance receptor that removes remnant lipoproteins and proteases from the extracellular space. In the absence of functional receptors, mouse embryos fail early in development, probably as a result of a failure to clear protease/antiprotease complexes from the surface of the invading trophoblast. A receptor-associated protein blocks the binding of all ligands and appears to function as a rapid regulator of receptor activity.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalCurrent opinion in lipidology
Issue number2
StatePublished - 1993

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


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