The LDL receptor

Joseph L. Goldstein; Michael S. Brown

doi:10.1161/ATVBAHA.108.179564

The LDL receptor

Joseph L. Goldstein, Michael S. Brown

Research output: Contribution to journal › Review article › peer-review

1016 Scopus citations

Abstract

In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

Original language	English (US)
Pages (from-to)	431-438
Number of pages	8
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1161/ATVBAHA.108.179564
State	Published - Apr 1 2009

Keywords

Cholesterol
Coronary heart disease
Familial hypercholesterolemia
Receptor-mediated endocytosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/ATVBAHA.108.179564

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AB - In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

KW - Cholesterol

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KW - Familial hypercholesterolemia

KW - Receptor-mediated endocytosis

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The LDL receptor

Abstract

Keywords

ASJC Scopus subject areas

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