The LDL receptor

Research output: Contribution to journalReview articlepeer-review

934 Scopus citations


In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number4
StatePublished - Apr 1 2009


  • Cholesterol
  • Coronary heart disease
  • Familial hypercholesterolemia
  • Receptor-mediated endocytosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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