Abstract
Background: Kto-Skd plays important roles in development. But the mechanism for how this complex regulates Hedgehog pathway is unknown. Results: Kto-Skd down-regulates ptc expression. Conclusion: Kto-Skd complex can regulate ptc expression by interacting with Ci. Significance: The finding that the Kto-Skd complex affects Hh pathway provides novel mechanistic insights into the regulation of A/P boundary formation in Drosophila wing discs.
Original language | English (US) |
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Pages (from-to) | 22333-22341 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 32 |
DOIs | |
State | Published - Aug 8 2014 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology