@article{e7c0791e2a754e38ac130df131707d79,
title = "The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity",
abstract = "Wang et al. report that lymphoid-tissue-inducer (LTi)-like cells from different tissues display heterogeneity. The maintenance of LTi-like cells in the mLN requires RANKL signaling from CD4+ T cells. LTi-like cells from the mLN control Tfh and subsequent humoral responses during intestinal immunization in an ID2- and PD-L1-dependent manner.",
keywords = "ID2, LTi-like cell, PD-L1, RANKL, T follicular helper cell",
author = "Wenyan Wang and Yiping Li and Jiacheng Hao and Yao He and Xin Dong and Fu, {Yang Xin} and Xiaohuan Guo",
note = "Funding Information: We are grateful to Dan R. Littman and Ivaylo Ivanov (New York University, NY) for Rorccre and Rorcgfp/+ mice; Anna Lasorella and Antonio Iavarone (Columbia University, NY) for Id2-floxed mice; Chen Dong (Tsinghua University, Beijing) for CD45.1 and OT-II Tg mice; Hai Qi (Tsinghua University, Beijing) for TCR? KO and CD274?/? mice, CCR7 antibody, and mCCL21; Elizabeth Hartland (The University of Melbourne, Melbourne) for OVA-expressing Citrobacter rodentium; Xin Lin (Tsinghua University, Beijing) for the CRISPR-Cas9 system; Wenling Han (Peking University, Beijing) for the pEGFPN1 plasmid; and Ju Qiu (Shanghai Institute of Nutrition and Health, Shanghai) for helpful discussions and comments on the manuscript. We also thank the Animal Facility at Tsinghua University for their support. This work was supported by the National Natural Science Foundation of China (91642106, 31570923, and 31821003 to X.G.; and 81901603 to W.W.), the National Key R&D Program of China (2017YFA0103602), the Thousand-Talent Young Investigator Program (to X.G.), Tsinghua University Initiative Scientific Research Program (2015Z21123 to X.G.), and the China Postdoctoral Science Foundation (to W.W.). The Guo laboratory was also supported by the Center for Life Sciences, the Institute for Immunology, and the School of Medicine at Tsinghua University. X.G. is the senior and corresponding author. X.G. conceived and designed the study. X.G. W.W. and Y.L. prepared the manuscript. W.W. and Y.L. performed all experiments and assisted in data analysis. J.H. Y.H. and X.D. participated in some experiments. Y.-X.F. provided critical materials and helpful suggestions on the project. The authors declare no competing interests. Funding Information: We are grateful to Dan R. Littman and Ivaylo Ivanov (New York University, NY) for Rorc cre and Rorc gfp/+ mice; Anna Lasorella and Antonio Iavarone (Columbia University, NY) for Id2-floxed mice; Chen Dong (Tsinghua University, Beijing) for CD45.1 and OT-II Tg mice; Hai Qi (Tsinghua University, Beijing) for TCRα KO and CD274 −/− mice, CCR7 antibody, and mCCL21; Elizabeth Hartland (The University of Melbourne, Melbourne) for OVA-expressing Citrobacter rodentium; Xin Lin (Tsinghua University, Beijing) for the CRISPR-Cas9 system; Wenling Han (Peking University, Beijing) for the pEGFPN1 plasmid; and Ju Qiu (Shanghai Institute of Nutrition and Health, Shanghai) for helpful discussions and comments on the manuscript. We also thank the Animal Facility at Tsinghua University for their support. This work was supported by the National Natural Science Foundation of China ( 91642106 , 31570923 , and 31821003 to X.G.; and 81901603 to W.W.), the National Key R&D Program of China ( 2017YFA0103602 ), the Thousand-Talent Young Investigator Program (to X.G.), Tsinghua University Initiative Scientific Research Program ( 2015Z21123 to X.G.), and the China Postdoctoral Science Foundation (to W.W.). The Guo laboratory was also supported by the Center for Life Sciences, the Institute for Immunology, and the School of Medicine at Tsinghua University . Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jul,
day = "21",
doi = "10.1016/j.celrep.2020.107936",
language = "English (US)",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}