TY - JOUR
T1 - The INO80 chromatin remodeling complex in transcription, replication and repair
AU - Conaway, Ronald C.
AU - Conaway, Joan Weliky
N1 - Funding Information:
Work in the authors’ laboratory is supported in part by National Institutes of Health Grant R37 GM41628.
PY - 2009/2
Y1 - 2009/2
N2 - The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
AB - The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
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U2 - 10.1016/j.tibs.2008.10.010
DO - 10.1016/j.tibs.2008.10.010
M3 - Review article
C2 - 19062292
AN - SCOPUS:59649124959
SN - 0376-5067
VL - 34
SP - 71
EP - 77
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 2
ER -