The induction of temperature-sensitive mutations in Drosophila melanogaster by the acridine mustard ICR-170

R. C. Woodruff; Rita M. Gander

doi:10.1016/0027-5107(74)90062-1

The induction of temperature-sensitive mutations in Drosophila melanogaster by the acridine mustard ICR-170

R. C. Woodruff, Rita M. Gander

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.

Original language	English (US)
Pages (from-to)	337-345
Number of pages	9
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0027-5107(74)90062-1
State	Published - Dec 1974

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Access to Document

10.1016/0027-5107(74)90062-1

Cite this

@article{aa802c229f644fc9a0a1db37f7aa1fd1,

title = "The induction of temperature-sensitive mutations in Drosophila melanogaster by the acridine mustard ICR-170",

abstract = "The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.",

author = "Woodruff, {R. C.} and Gander, {Rita M.}",

year = "1974",

month = dec,

doi = "10.1016/0027-5107(74)90062-1",

language = "English (US)",

volume = "25",

pages = "337--345",

journal = "Mutation Research",

issn = "0027-5107",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - The induction of temperature-sensitive mutations in Drosophila melanogaster by the acridine mustard ICR-170

AU - Woodruff, R. C.

AU - Gander, Rita M.

PY - 1974/12

Y1 - 1974/12

N2 - The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.

AB - The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.

UR - http://www.scopus.com/inward/record.url?scp=0016246711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016246711&partnerID=8YFLogxK

U2 - 10.1016/0027-5107(74)90062-1

DO - 10.1016/0027-5107(74)90062-1

M3 - Article

C2 - 4215971

AN - SCOPUS:0016246711

SN - 0027-5107

VL - 25

SP - 337

EP - 345

JO - Mutation Research

JF - Mutation Research

IS - 3

ER -

The induction of temperature-sensitive mutations in Drosophila melanogaster by the acridine mustard ICR-170

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this