The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes

Masaki Mizuno; Norio Hotta; Rie Ishizawa; Han Kyul Kim; Gary Iwamoto; Wanpen Vongpatanasin; Jere H. Mitchell; Scott A. Smith

doi:10.1249/JES.0000000000000259

The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes

Masaki Mizuno, Norio Hotta, Rie Ishizawa, Han Kyul Kim, Gary Iwamoto, Wanpen Vongpatanasin, Jere H. Mitchell, Scott A. Smith

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.

Original language	English (US)
Pages (from-to)	157-167
Number of pages	11
Journal	Exercise and Sport Sciences Reviews
Volume	49
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000259
State	Published - 2021

Keywords

central command
diabetes
exercise blood pressure
exercise pressor reflex
hyperglycemia
insulin resistance
sympathetic nerve activity

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000259

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title = "The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes",

abstract = "Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.",

keywords = "central command, diabetes, exercise blood pressure, exercise pressor reflex, hyperglycemia, insulin resistance, sympathetic nerve activity",

author = "Masaki Mizuno and Norio Hotta and Rie Ishizawa and Kim, {Han Kyul} and Gary Iwamoto and Wanpen Vongpatanasin and Mitchell, {Jere H.} and Smith, {Scott A.}",

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AU - Mizuno, Masaki

AU - Hotta, Norio

AU - Ishizawa, Rie

AU - Kim, Han Kyul

AU - Iwamoto, Gary

AU - Vongpatanasin, Wanpen

AU - Mitchell, Jere H.

AU - Smith, Scott A.

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2021

Y1 - 2021

N2 - Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.

AB - Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.

KW - central command

KW - diabetes

KW - exercise blood pressure

KW - exercise pressor reflex

KW - hyperglycemia

KW - insulin resistance

KW - sympathetic nerve activity

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JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

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ER -

The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes

Abstract

Keywords

ASJC Scopus subject areas

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