The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

Medicine & Life Sciences

• LY 295427 100%
• Oxysterols 50%
• Cholesterol 32%
• Homeostasis 32%
• Up-Regulation 31%
• Insulin 29%
• Genes 17%
• SREBP cleavage-activating protein 16%
• Proteins 16%
• Sterol Regulatory Element Binding Proteins 6%
• Liver X Receptors 5%
• Gene Expression 5%
• Sterols 5%
• RNA Interference 4%