The Hippo Signaling Pathway in Development and Disease

Yonggang Zheng; Duojia Pan

doi:10.1016/j.devcel.2019.06.003

The Hippo Signaling Pathway in Development and Disease

Yonggang Zheng, Duojia Pan

Research output: Contribution to journal › Review article › peer-review

518 Scopus citations

Abstract

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.

Original language	English (US)
Pages (from-to)	264-282
Number of pages	19
Journal	Developmental cell
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2019.06.003
State	Published - Aug 5 2019

Keywords

NF2
TAZ
TEAD
YAP
actomyosin
adherens junction
cancer
cell polarity
cytoskeleton
growth control
hippo signaling
mechanotransduction
merlin
neurofibromatosis
oncogene
regeneration
scalloped
spectrin
tissue homeostasis
tumor suppressor
yorkie

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.06.003

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title = "The Hippo Signaling Pathway in Development and Disease",

abstract = "The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.",

keywords = "NF2, TAZ, TEAD, YAP, actomyosin, adherens junction, cancer, cell polarity, cytoskeleton, growth control, hippo signaling, mechanotransduction, merlin, neurofibromatosis, oncogene, regeneration, scalloped, spectrin, tissue homeostasis, tumor suppressor, yorkie",

author = "Yonggang Zheng and Duojia Pan",

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KW - TAZ

KW - TEAD

KW - YAP

KW - actomyosin

KW - adherens junction

KW - cancer

KW - cell polarity

KW - cytoskeleton

KW - growth control

KW - hippo signaling

KW - mechanotransduction

KW - merlin

KW - neurofibromatosis

KW - oncogene

KW - regeneration

KW - scalloped

KW - spectrin

KW - tissue homeostasis

KW - tumor suppressor

KW - yorkie

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JO - Developmental cell

JF - Developmental cell

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The Hippo Signaling Pathway in Development and Disease

Abstract

Keywords

ASJC Scopus subject areas

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