The Hippo Signaling Pathway in Development and Disease

Research output: Contribution to journalReview articlepeer-review

397 Scopus citations


The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in multiple human diseases. This Review from Zheng and Pan provides an updated overview of the pathway and its roles in development, homeostasis, and disease. The authors also discuss outstanding questions and opportunities for Hippo-targeted therapies.

Original languageEnglish (US)
Pages (from-to)264-282
Number of pages19
JournalDevelopmental cell
Issue number3
StatePublished - Aug 5 2019


  • NF2
  • TAZ
  • TEAD
  • YAP
  • actomyosin
  • adherens junction
  • cancer
  • cell polarity
  • cytoskeleton
  • growth control
  • hippo signaling
  • mechanotransduction
  • merlin
  • neurofibromatosis
  • oncogene
  • regeneration
  • scalloped
  • spectrin
  • tissue homeostasis
  • tumor suppressor
  • yorkie

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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