TY - JOUR
T1 - The heart-liver metabolic axis
T2 - Defective communication exacerbates disease
AU - Baskin, Kedryn K.
AU - Bookout, Angie L.
AU - Olson, Eric N.
PY - 2014/4
Y1 - 2014/4
N2 - The heart has been recognized as an endocrine organ for over 30 years (de Bold, 2011); however, little is known about how the heart communicates with other organs in the body, and even less is known about this process in the diseased heart. In this issue of EMBO Molecular Medicine, Magida and Leinwand (2014) introduce the concept that a primary genetic defect in the heart results in aberrant hepatic lipid metabolism, which consequently exacerbates hypertrophic cardiomyopathy (HCM). This study provides evidence in support of the hypothesis that crosstalk occurs between the heart and liver, and that this becomes disrupted in the diseased state. Baskin, Bookout and Olson discuss a paper by Magida & Leiwand in this issue, which provides evidence that crosstalk occurs between the heart and liver, and that this becomes disrupted in the diseased state.
AB - The heart has been recognized as an endocrine organ for over 30 years (de Bold, 2011); however, little is known about how the heart communicates with other organs in the body, and even less is known about this process in the diseased heart. In this issue of EMBO Molecular Medicine, Magida and Leinwand (2014) introduce the concept that a primary genetic defect in the heart results in aberrant hepatic lipid metabolism, which consequently exacerbates hypertrophic cardiomyopathy (HCM). This study provides evidence in support of the hypothesis that crosstalk occurs between the heart and liver, and that this becomes disrupted in the diseased state. Baskin, Bookout and Olson discuss a paper by Magida & Leiwand in this issue, which provides evidence that crosstalk occurs between the heart and liver, and that this becomes disrupted in the diseased state.
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U2 - 10.1002/emmm.201303800
DO - 10.1002/emmm.201303800
M3 - Article
C2 - 24623378
AN - SCOPUS:84898600335
SN - 1757-4676
VL - 6
SP - 436
EP - 438
JO - EMBO Molecular Medicine
JF - EMBO Molecular Medicine
IS - 4
ER -