The genotoxicity of alpha particles in human embryonic skin fibroblasts

D. J. Chen, G. F. Strniste, N. Tokita

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Cell inactivation and induced mutation frequencies at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus have been measured in cultured human fibroblasts (GM10) exposed to α particles from 238Pu (LET at the cell surface was 100 keV/μm) and 250 kVp X rays. The survival curves resulting from exposure to α particles are exponential. The mean lethal dose, D0, is approximately 1.3 Gy for X rays and 0.25 Gy for α particles. As a function of radiation dose, mutation induction at the HGPRT locus was linear for α particles whereas the X-ray-induced mutation data were better fitted by a quadratic function. When mutation frequencies were plotted against the log of survival, mutation frequency at a given survival level was greater in cells exposed to α particles than to X rays.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalRadiation research
Issue number2
StatePublished - 1984

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging


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