Abstract
Negatively selected mouse and rat lymphocyte populations, specifically deprived of alloreactivity to a particular major histocompatibility complex (MHC) haplotype, are nevertheless fully capable of responding to trinitrophenyl (TNP)-modified allogeneic stimulator cells and developing cytotoxic T-lymphocyte activity to TNP-altered allogeneic target cells. As for syngeneic systems, lytic expression of those responder killer cells also requires MHC identity between the target and stimulator cell populations. Such a finding argues strongly against two variations of the dual recognition hypothesis: like-like interactions and adaptive differentiation. Instead, these data favor either the altered self model or a third variation of the dual receptor model, where one of the relevent receptors is specific for the modifying antigen and the second is a low affinity receptor unable to be triggered in the absence of a modifying antigen.
Original language | English (US) |
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Pages (from-to) | 361-367 |
Number of pages | 7 |
Journal | Journal of Experimental Medicine |
Volume | 146 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1 1977 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology