Murine and chimeric RFB4 (anti-human CD22) monoclonal antibodies (MAbs) with mutations in their Fc portions were conjugated to recombinant ricin toxin A chain to generate immunotoxins. The resulting immunotoxins (ITs) constructed with chimeric RFB4 MAbs were designed to have longer or shorter half-lives but similar binding and cytotoxic properties. These ITs can now be evaluated in vivo for improved therapeutic indices. The characteristics of these ITs are the subject of this report.
|Original language||English (US)|
|Number of pages||12|
|State||Published - Jul 1 2005|
- Fc mutations
- Ricin A chain
ASJC Scopus subject areas
- Immunology and Allergy