The functional universe of membrane contact sites

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations


Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to environmental and developmental changes. One way in which organelles communicate and integrate their activities is by forming close contacts, often called ‘membrane contact sites’ (MCSs). Interest in MCSs has grown dramatically in the past decade as it is has become clear that they are ubiquitous and have a much broader range of critical roles in cells than was initially thought. Indeed, functions for MCSs in intracellular signalling (particularly calcium signalling, reactive oxygen species signalling and lipid signalling), autophagy, lipid metabolism, membrane dynamics, cellular stress responses and organelle trafficking and biogenesis have now been reported.

Original languageEnglish (US)
Pages (from-to)7-24
Number of pages18
JournalNature Reviews Molecular Cell Biology
Issue number1
StatePublished - Jan 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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