Abstract
Clinical use of functional magnetic resonance imaging (fMRI) in obsessive-compulsive disorder (OCD) is limited by a relative absence of fMRI task development, standardization, and normative performance databases. We investigated the fMRI-based verbal fluency test (f-VFT) by quantitatively evaluating brain activation patterns in OCD participants (8 females and 4 males) compared with a normative database (16 females and 16 males). At the group level, OCD participants and references had highly similar activation in left-hemisphere language regions, including the precentral/premotor cortex, thalamus, basal ganglia, and inferior frontal gyrus/frontal operculum. At the interindividual level, however, the OCD group had highly variable activation patterns in the dorsal and ventral regions of the pre-supplementary motor area (pre-SMA) that may correspond with differences in demographic and clinical variables. Further, there were significant correlations in the OCD participants between pre-SMA dorsal and ventral activation and between dorsal pre-SMA activation and perfectionism. Our findings suggest considerable functional anatomical overlap in left-hemisphere language regions between OCD participants and references but significantly higher pre-SMA interindividual variability in OCD compared to the reference group that may be relevant in clinical fMRI application and the theoretical understanding of OCD.
Original language | English (US) |
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Pages (from-to) | 424-440 |
Number of pages | 17 |
Journal | Neurocase |
Volume | 18 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2012 |
Keywords
- Controlled oral word association test
- Functional magnetic resonance imaging
- Functional neuroimaging
- Individual differences
- Neuropsychology
- Obsessive-compulsive disorder
- Pre-supplementary motor area
- Verbal fluency
- fMRI
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology