This review focuses on the inositol phosphate Ca2+ signalling pathway in Xenopus oocytes. The known characteristics of the individual elements of this cascade - from the membrane receptors to the intracellular Ca2+ stores - will be covered. Based on this knowledge, a simple model will then try to account for the behaviour of the newly recognized oscillations of free intracellular Ca2+ and propagated Ca2+ waves. Finally, some of the potential physiological functions of the inositol phosphate pathway will be summarized. Although there is no systematic attempt to contrast the findings in the oocyte to those in other cells, the readers of this journal will not fail to notice a high degree of similarity. Although this may seem unexciting at first, it suggests that the inositol phosphate signalling pathway may be strikingly conserved across species.
|Original language||English (US)|
|Number of pages||11|
|State||Published - Jan 1 1991|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology