The fine structure of nuclear changes in superior limbic keratoconjunctivitis

H. B. Collin; P. C. Donshik; S. A. Boruchoff; C. S. Foster; Harrison D Cavanagh

The fine structure of nuclear changes in superior limbic keratoconjunctivitis

H. B. Collin, P. C. Donshik, S. A. Boruchoff, C. S. Foster, Harrison D Cavanagh

Research output: Contribution to journal › Article › peer-review

Abstract

Superior limbic keratoconjunctivitis (SLK) is a condition of unknown etiology. Histological signs include acanthosis, dyskeratosis, keratinization and balloon degeneration of the bulbar conjunctival epithelium. Ultrastructural examination of biopsy material from five eyes of patients with SLK shows numerous nuclear changes in the conjunctival epithelial cells. These include abnormal distribution and aggregation of nuclear chromatin, the presence of filaments within the nucleus, and dense accumulations of cytoplasmic filaments which surround the nucleus, resulting in 'strangulation' and the formation of multilobed nuclei or multinucleated cells. These changes do not appear to have been described previously in any cell type.

Original language	English (US)
Pages (from-to)	79-84
Number of pages	6
Journal	Investigative Ophthalmology and Visual Science
Volume	17
Issue number	1
State	Published - Oct 16 1978

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Cite this

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title = "The fine structure of nuclear changes in superior limbic keratoconjunctivitis",

abstract = "Superior limbic keratoconjunctivitis (SLK) is a condition of unknown etiology. Histological signs include acanthosis, dyskeratosis, keratinization and balloon degeneration of the bulbar conjunctival epithelium. Ultrastructural examination of biopsy material from five eyes of patients with SLK shows numerous nuclear changes in the conjunctival epithelial cells. These include abnormal distribution and aggregation of nuclear chromatin, the presence of filaments within the nucleus, and dense accumulations of cytoplasmic filaments which surround the nucleus, resulting in 'strangulation' and the formation of multilobed nuclei or multinucleated cells. These changes do not appear to have been described previously in any cell type.",

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AU - Collin, H. B.

AU - Donshik, P. C.

AU - Boruchoff, S. A.

AU - Foster, C. S.

AU - Cavanagh, Harrison D

PY - 1978/10/16

Y1 - 1978/10/16

N2 - Superior limbic keratoconjunctivitis (SLK) is a condition of unknown etiology. Histological signs include acanthosis, dyskeratosis, keratinization and balloon degeneration of the bulbar conjunctival epithelium. Ultrastructural examination of biopsy material from five eyes of patients with SLK shows numerous nuclear changes in the conjunctival epithelial cells. These include abnormal distribution and aggregation of nuclear chromatin, the presence of filaments within the nucleus, and dense accumulations of cytoplasmic filaments which surround the nucleus, resulting in 'strangulation' and the formation of multilobed nuclei or multinucleated cells. These changes do not appear to have been described previously in any cell type.

AB - Superior limbic keratoconjunctivitis (SLK) is a condition of unknown etiology. Histological signs include acanthosis, dyskeratosis, keratinization and balloon degeneration of the bulbar conjunctival epithelium. Ultrastructural examination of biopsy material from five eyes of patients with SLK shows numerous nuclear changes in the conjunctival epithelial cells. These include abnormal distribution and aggregation of nuclear chromatin, the presence of filaments within the nucleus, and dense accumulations of cytoplasmic filaments which surround the nucleus, resulting in 'strangulation' and the formation of multilobed nuclei or multinucleated cells. These changes do not appear to have been described previously in any cell type.

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The fine structure of nuclear changes in superior limbic keratoconjunctivitis

Abstract

ASJC Scopus subject areas

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