The fine structure of nuclear changes in superior limbic keratoconjunctivitis

H. B. Collin, P. C. Donshik, S. A. Boruchoff, C. S. Foster, Harrison D Cavanagh

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Superior limbic keratoconjunctivitis (SLK) is a condition of unknown etiology. Histological signs include acanthosis, dyskeratosis, keratinization and balloon degeneration of the bulbar conjunctival epithelium. Ultrastructural examination of biopsy material from five eyes of patients with SLK shows numerous nuclear changes in the conjunctival epithelial cells. These include abnormal distribution and aggregation of nuclear chromatin, the presence of filaments within the nucleus, and dense accumulations of cytoplasmic filaments which surround the nucleus, resulting in 'strangulation' and the formation of multilobed nuclei or multinucleated cells. These changes do not appear to have been described previously in any cell type.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number1
StatePublished - Oct 16 1978

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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