The expanding role of BAP1 in clear cell renal cell carcinoma

Payal Kapur; Satwik Rajaram; James Brugarolas

doi:10.1016/j.humpath.2022.07.022

The expanding role of BAP1 in clear cell renal cell carcinoma

Payal Kapur, Satwik Rajaram, James Brugarolas

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.

Original language	English (US)
Pages (from-to)	22-31
Number of pages	10
Journal	Human Pathology
Volume	133
DOIs	https://doi.org/10.1016/j.humpath.2022.07.022
State	Published - Mar 2023

Keywords

BAP1
PBRM1
RCC
ccRCC

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.humpath.2022.07.022

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title = "The expanding role of BAP1 in clear cell renal cell carcinoma",

abstract = "Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.",

keywords = "BAP1, PBRM1, RCC, ccRCC",

author = "Payal Kapur and Satwik Rajaram and James Brugarolas",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2023",

month = mar,

doi = "10.1016/j.humpath.2022.07.022",

language = "English (US)",

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T1 - The expanding role of BAP1 in clear cell renal cell carcinoma

AU - Kapur, Payal

AU - Rajaram, Satwik

AU - Brugarolas, James

PY - 2023/3

Y1 - 2023/3

N2 - Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.

AB - Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.

KW - BAP1

KW - PBRM1

KW - RCC

KW - ccRCC

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U2 - 10.1016/j.humpath.2022.07.022

DO - 10.1016/j.humpath.2022.07.022

M3 - Review article

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AN - SCOPUS:85138203801

SN - 0046-8177

VL - 133

SP - 22

EP - 31

JO - Human Pathology

JF - Human Pathology

ER -

The expanding role of BAP1 in clear cell renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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