The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm

James Brugarolas; Satwik Rajaram; Alana Christie; Payal Kapur

doi:10.1016/j.ccell.2020.10.021

The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm

James Brugarolas, Satwik Rajaram, Alana Christie, Payal Kapur

Research output: Contribution to journal › Comment/debate › peer-review

24 Scopus citations

Abstract

Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.

Original language	English (US)
Pages (from-to)	771-773
Number of pages	3
Journal	Cancer Cell
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2020.10.021
State	Published - Dec 14 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm",

abstract = "Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.",

author = "James Brugarolas and Satwik Rajaram and Alana Christie and Payal Kapur",

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AU - Brugarolas, James

AU - Rajaram, Satwik

AU - Christie, Alana

AU - Kapur, Payal

PY - 2020/12/14

Y1 - 2020/12/14

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AB - Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.

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The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm

Abstract

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