@article{489b07320d8948458cd0bdd445c2ba7e,
title = "The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm",
abstract = "Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.",
author = "James Brugarolas and Satwik Rajaram and Alana Christie and Payal Kapur",
note = "Funding Information: J.B., A.C., and P.K. are supported by NIH ( P50 CA196516 ) and by the Cancer Research & Prevention Institute of Texas (CPRIT; RP180192 ). J.B. and A.C. are also supported by CPRIT ( RP180191 ). P.K. is supported by NIH ( R01CA244579 , R01CA154475 , and R01DK115986 ), DOD ( W81XWH1910710 ), and CPRIT ( RP200233 ). S.R. is supported by startup funds provided through the Lyda Hill Department of Bioinformatics . Funding Information: J.B. is a consultant for and has received research funding from Arrowhead Pharmaceuticals and is a consultant for Exelixis. J.B. holds US Patent No. 15/761,534. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = dec,
day = "14",
doi = "10.1016/j.ccell.2020.10.021",
language = "English (US)",
volume = "38",
pages = "771--773",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",
}