The eureka enzyme: The discovery of DNA polymerase

Errol C. Friedberg

doi:10.1038/nrm1787

The eureka enzyme: The discovery of DNA polymerase

Errol C. Friedberg

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an enzyme - DNA polymerase I of Escherichia coli - that catalysed the stable incorporation of deoxyribonucleotides into DNA in vitro came as a surprise. At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Nature Reviews Molecular Cell Biology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1038/nrm1787
State	Published - Feb 2006

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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The eureka enzyme: The discovery of DNA polymerase

Abstract

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