TY - JOUR
T1 - The effects of low- and hyper-Dk contact lenses on corneal epithelial homeostasis
AU - Cavanagh, Harrison D
N1 - Funding Information:
This article was supported by EY 10738 and an unrestricted research grant from Research to Prevent Blindness, New York, New York.
PY - 2003/9
Y1 - 2003/9
N2 - Contact lens wear and eyelid suturing diminish overall Bcl-2 expression in the corneal epithelium, yet nuclear Bcl-2 in the exposed surface epithelial cells seems to be retained for longer periods when compared with the retention in control eyes. This observation may explain why there is a decrease in surface cell exfoliation during CTL wear, because nuclear Bcl-2 loss needs to precede apoptotic surface cell exfoliation. In addition, if the hypothesis is true that Bcl-2 also has a regulatory function in the proliferation and differentiation of tissues, the overall reduced expression of Bcl-2 (nuclear plus cytoplasmic) may clarify the decrease in proliferation of the corneal epithelium seen during CTL wear. Future studies should clarify the role of Bcl-2 in the homeostatic dynamics of the corneal epithelium. CTL wear and eyelid suturing provide excellent noninflammatory models to advance knowledge of Bcl-2 and its regulatory roles. Additionally, these models should help researchers gain a better understanding of the CTL-associated effects on corneal epithelium.
AB - Contact lens wear and eyelid suturing diminish overall Bcl-2 expression in the corneal epithelium, yet nuclear Bcl-2 in the exposed surface epithelial cells seems to be retained for longer periods when compared with the retention in control eyes. This observation may explain why there is a decrease in surface cell exfoliation during CTL wear, because nuclear Bcl-2 loss needs to precede apoptotic surface cell exfoliation. In addition, if the hypothesis is true that Bcl-2 also has a regulatory function in the proliferation and differentiation of tissues, the overall reduced expression of Bcl-2 (nuclear plus cytoplasmic) may clarify the decrease in proliferation of the corneal epithelium seen during CTL wear. Future studies should clarify the role of Bcl-2 in the homeostatic dynamics of the corneal epithelium. CTL wear and eyelid suturing provide excellent noninflammatory models to advance knowledge of Bcl-2 and its regulatory roles. Additionally, these models should help researchers gain a better understanding of the CTL-associated effects on corneal epithelium.
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U2 - 10.1016/S0896-1549(03)00044-0
DO - 10.1016/S0896-1549(03)00044-0
M3 - Review article
C2 - 14564755
AN - SCOPUS:0141704170
SN - 0896-1549
VL - 16
SP - 311
EP - 325
JO - Ophthalmology Clinics of North America
JF - Ophthalmology Clinics of North America
IS - 3
ER -