The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study

William A. Hendrickse; Howard P. Roffwarg; Bruce D. Grannemann; Paul J. Orsulak; Roseanne Armitage; John W. Cain; John Battaglia; John R. Debus; A. John Rush

doi:10.1038/npp.1994.10

The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study

William A. Hendrickse, Howard P. Roffwarg, Bruce D. Grannemann, Paul J. Orsulak, Roseanne Armitage, John W. Cain, John Battaglia, John R. Debus, A. John Rush

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.

Original language	English (US)
Pages (from-to)	85-91
Number of pages	7
Journal	Neuropsychopharmacology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1038/npp.1994.10
State	Published - Apr 1994

Keywords

Depression
Fluoxetine
Norfluoxetine
Polysomnography
Serotonin

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health

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10.1038/npp.1994.10

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title = "The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study",

abstract = "The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.",

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note = "Funding Information: This study was supported in part by grants from the National Institute of Mental Health to A. J. Rush (MH-35370) and to the Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas (MH-41115), by the Department of Veterans Affairs Medical Center, Dallas, Texas, and by a Veterans Administration Research Training Grant to W. A. Hendrickse.",

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AU - Rush, A. John

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The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study

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