Fed, male adult rats were given an i.p. injection of CoCl2 (25 mg./Kg.) after pretreatment with nicotinamide (750 mg./Kg.) to reduce the mortality rate. A trasient hyperglycemic phase was observed during the first hour after the injection and was accompanied by a significant increase in plasma glucagon levels, suggesting that the hyperglycemia may be due to a release of glucagon from the alpha cells. No evidence of significant depletion of pancreatic glucagon was observed during the 3 days after treatment nor did glucagon levels decline significantly at any time. It is suggested that, in the rat, CoCl2 is more "alphacytotropic" than "alphacytotoxic" in its action and is ineffective in inducing even a temporary glucagon deficiency.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism