The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat

H. Sakurai; R. E. Dobbs; Roger H Unger

doi:10.1007/BF00429911

The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat

H. Sakurai, R. E. Dobbs, Roger H Unger

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46 Scopus citations

Abstract

The effects of somatostatin on GLI release during the absorption of intraduodenally administered glucose, casein hydrolysate and longchain triglycerides were studied in conscious dogs. Whereas, after an intraduodenal glucose load, GLI rose promptly in saline-infused control experiments to a peak of 5 ng/ml (SEM ± 4) in 60 minutes, significantly lower values were observed during somatostatin infusion (P<0.025 - 0.05). A similar reduction in the magnitude of the GLI response to intraduodenally administered casein hydrolysate (P<0.05) and fat (p<0.05) was observed.

Original language	English (US)
Pages (from-to)	427-430
Number of pages	4
Journal	Diabetologia
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/BF00429911
State	Published - Oct 1975

Keywords

Glucagon-like immunoreactivity (GLI)
fat
glucagon
glucose
insulin
protein meal
somatostatin
triglyceride

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1007/BF00429911

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abstract = "The effects of somatostatin on GLI release during the absorption of intraduodenally administered glucose, casein hydrolysate and longchain triglycerides were studied in conscious dogs. Whereas, after an intraduodenal glucose load, GLI rose promptly in saline-infused control experiments to a peak of 5 ng/ml (SEM ± 4) in 60 minutes, significantly lower values were observed during somatostatin infusion (P<0.025 - 0.05). A similar reduction in the magnitude of the GLI response to intraduodenally administered casein hydrolysate (P<0.05) and fat (p<0.05) was observed.",

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AU - Dobbs, R. E.

AU - Unger, Roger H

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AB - The effects of somatostatin on GLI release during the absorption of intraduodenally administered glucose, casein hydrolysate and longchain triglycerides were studied in conscious dogs. Whereas, after an intraduodenal glucose load, GLI rose promptly in saline-infused control experiments to a peak of 5 ng/ml (SEM ± 4) in 60 minutes, significantly lower values were observed during somatostatin infusion (P<0.025 - 0.05). A similar reduction in the magnitude of the GLI response to intraduodenally administered casein hydrolysate (P<0.05) and fat (p<0.05) was observed.

KW - Glucagon-like immunoreactivity (GLI)

KW - fat

KW - glucagon

KW - glucose

KW - insulin

KW - protein meal

KW - somatostatin

KW - triglyceride

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The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat

Abstract

Keywords

ASJC Scopus subject areas

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