The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery

Cynthia Gyamfi; Lisa Mele; Ronald J. Wapner; Catherine Y. Spong; Alan Peaceman; Yoram Sorokin; Donald J. Dudley; Francee Johnson; Kenneth J. Leveno; Steve N. Caritis; Brian M. Mercer; John M. Thorp; Mary J. O'Sullivan; Susan M. Ramin; Marshall Carpenter; Dwight J. Rouse; Menachem Miodovnik; Baha Sibai

doi:10.1016/j.ajog.2010.04.047

The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery

Cynthia Gyamfi, Lisa Mele, Ronald J. Wapner, Catherine Y. Spong, Alan Peaceman, Yoram Sorokin, Donald J. Dudley, Francee Johnson, Kenneth J. Leveno, Steve N. Caritis, Brian M. Mercer, John M. Thorp, Mary J. O'Sullivan, Susan M. Ramin, Marshall Carpenter, Dwight J. Rouse, Menachem Miodovnik, Baha Sibai

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Objective: Antenatal corticosteroids (ACS) decrease respiratory distress syndrome in singleton gestations. Twin data are less clear. Obesity and body mass index (BMI) also affect medication distribution volume. We evaluated whether maternal or neonatal cord betamethasone concentrations differed in twin gestations or obese patients. Study Design: Participants receiving betamethasone in a randomized controlled trial of weekly ACS were identified. We analyzed maternal delivery and cord serum betamethasone concentrations comparing singletons with twins and obese (BMI ≥30 kg/m²) with nonobese women. Results: Fifty-five maternal and 45 cord blood samples were available. Unadjusted median maternal serum concentrations appeared paradoxically higher in both twin gestations and the obese. However, after controlling for confounders, there were no differences in betamethasone concentrations in maternal serum or cord blood between singletons and twins (P = .61 vs P = .14) or nonobese and obese women (P = .67 vs .12). Conclusion: Maternal and umbilical cord blood serum betamethasone concentrations are not different in twin gestations or obese women.

Original language	English (US)
Pages (from-to)	219.e1-219.e5
Journal	American journal of obstetrics and gynecology
Volume	203
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2010.04.047
State	Published - Sep 2010

Keywords

betamethasone concentration
obesity
twins

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2010.04.047

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Gyamfi, C., Mele, L., Wapner, R. J., Spong, C. Y., Peaceman, A., Sorokin, Y., Dudley, D. J., Johnson, F., Leveno, K. J., Caritis, S. N., Mercer, B. M., Thorp, J. M., O'Sullivan, M. J., Ramin, S. M., Carpenter, M., Rouse, D. J., Miodovnik, M., & Sibai, B. (2010). The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery. American journal of obstetrics and gynecology, 203(3), 219.e1-219.e5. https://doi.org/10.1016/j.ajog.2010.04.047

Gyamfi, C, Mele, L, Wapner, RJ, Spong, CY, Peaceman, A, Sorokin, Y, Dudley, DJ, Johnson, F, Leveno, KJ, Caritis, SN, Mercer, BM, Thorp, JM, O'Sullivan, MJ, Ramin, SM, Carpenter, M, Rouse, DJ, Miodovnik, M & Sibai, B 2010, 'The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery', American journal of obstetrics and gynecology, vol. 203, no. 3, pp. 219.e1-219.e5. https://doi.org/10.1016/j.ajog.2010.04.047

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abstract = "Objective: Antenatal corticosteroids (ACS) decrease respiratory distress syndrome in singleton gestations. Twin data are less clear. Obesity and body mass index (BMI) also affect medication distribution volume. We evaluated whether maternal or neonatal cord betamethasone concentrations differed in twin gestations or obese patients. Study Design: Participants receiving betamethasone in a randomized controlled trial of weekly ACS were identified. We analyzed maternal delivery and cord serum betamethasone concentrations comparing singletons with twins and obese (BMI ≥30 kg/m2) with nonobese women. Results: Fifty-five maternal and 45 cord blood samples were available. Unadjusted median maternal serum concentrations appeared paradoxically higher in both twin gestations and the obese. However, after controlling for confounders, there were no differences in betamethasone concentrations in maternal serum or cord blood between singletons and twins (P = .61 vs P = .14) or nonobese and obese women (P = .67 vs .12). Conclusion: Maternal and umbilical cord blood serum betamethasone concentrations are not different in twin gestations or obese women.",

keywords = "betamethasone concentration, obesity, twins",

author = "Cynthia Gyamfi and Lisa Mele and Wapner, {Ronald J.} and Spong, {Catherine Y.} and Alan Peaceman and Yoram Sorokin and Dudley, {Donald J.} and Francee Johnson and Leveno, {Kenneth J.} and Caritis, {Steve N.} and Mercer, {Brian M.} and Thorp, {John M.} and O'Sullivan, {Mary J.} and Ramin, {Susan M.} and Marshall Carpenter and Rouse, {Dwight J.} and Menachem Miodovnik and Baha Sibai",

year = "2010",

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doi = "10.1016/j.ajog.2010.04.047",

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AU - Gyamfi, Cynthia

AU - Mele, Lisa

AU - Wapner, Ronald J.

AU - Spong, Catherine Y.

AU - Peaceman, Alan

AU - Sorokin, Yoram

AU - Dudley, Donald J.

AU - Johnson, Francee

AU - Leveno, Kenneth J.

AU - Caritis, Steve N.

AU - Mercer, Brian M.

AU - Thorp, John M.

AU - O'Sullivan, Mary J.

AU - Ramin, Susan M.

AU - Carpenter, Marshall

AU - Rouse, Dwight J.

AU - Miodovnik, Menachem

AU - Sibai, Baha

PY - 2010/9

Y1 - 2010/9

N2 - Objective: Antenatal corticosteroids (ACS) decrease respiratory distress syndrome in singleton gestations. Twin data are less clear. Obesity and body mass index (BMI) also affect medication distribution volume. We evaluated whether maternal or neonatal cord betamethasone concentrations differed in twin gestations or obese patients. Study Design: Participants receiving betamethasone in a randomized controlled trial of weekly ACS were identified. We analyzed maternal delivery and cord serum betamethasone concentrations comparing singletons with twins and obese (BMI ≥30 kg/m2) with nonobese women. Results: Fifty-five maternal and 45 cord blood samples were available. Unadjusted median maternal serum concentrations appeared paradoxically higher in both twin gestations and the obese. However, after controlling for confounders, there were no differences in betamethasone concentrations in maternal serum or cord blood between singletons and twins (P = .61 vs P = .14) or nonobese and obese women (P = .67 vs .12). Conclusion: Maternal and umbilical cord blood serum betamethasone concentrations are not different in twin gestations or obese women.

AB - Objective: Antenatal corticosteroids (ACS) decrease respiratory distress syndrome in singleton gestations. Twin data are less clear. Obesity and body mass index (BMI) also affect medication distribution volume. We evaluated whether maternal or neonatal cord betamethasone concentrations differed in twin gestations or obese patients. Study Design: Participants receiving betamethasone in a randomized controlled trial of weekly ACS were identified. We analyzed maternal delivery and cord serum betamethasone concentrations comparing singletons with twins and obese (BMI ≥30 kg/m2) with nonobese women. Results: Fifty-five maternal and 45 cord blood samples were available. Unadjusted median maternal serum concentrations appeared paradoxically higher in both twin gestations and the obese. However, after controlling for confounders, there were no differences in betamethasone concentrations in maternal serum or cord blood between singletons and twins (P = .61 vs P = .14) or nonobese and obese women (P = .67 vs .12). Conclusion: Maternal and umbilical cord blood serum betamethasone concentrations are not different in twin gestations or obese women.

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The effect of plurality and obesity on betamethasone concentrations in women at risk for preterm delivery

Abstract

Keywords

ASJC Scopus subject areas

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