The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis

Maria M. París, Sheila M. Hickey, Mónica Trujillo, Amina Ahmed, Kurt Olsen, George H. McCracken

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 μg significantly reduced tumor necrosis factor-α (TNFα) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined.

Original languageEnglish (US)
Pages (from-to)1239-1246
Number of pages8
JournalJournal of Infectious Diseases
Issue number5
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


Dive into the research topics of 'The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis'. Together they form a unique fingerprint.

Cite this