The effect of epidural anaesthesia with 1% lidocaine on the pressor response to dynamic exercise in man.

D. B. Friedman, J. Brennum, F. Sztuk, O. B. Hansen, P. S. Clifford, F. W. Bach, L. Arendt-Nielsen, J. H. Mitchell, N. H. Secher

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


1. In order to examine the sensitivity to local anaesthetics of afferent neural feedback from working muscle during dynamic exercise, sixteen subjects cycled for 12 min before and after epidural anaesthesia using 1% lidocaine. The presence of afferent neural blockade was verified by elimination of the blood pressure response to a cold pressor test, laser‐induced evoked potentials and increases in pain detection and tolerance thresholds of the foot. Conversely, epidural anaesthesia had no effect on these variables in the unblocked skin areas or on electrically evoked potentials in blocked or unblocked skin. 2. During dynamic exercise, heart rate increased as did mean arterial pressure and cardiac output. Mean arterial pressure remained at the exercise level during post‐exercise ischaemia, but heart rate and cardiac output decreased while total peripheral resistance increased. Epidural anaesthesia did not significantly affect these variables during rest, dynamic exercise, post‐exercise ischaemia or recovery. 3. The results of this study show that, in order to affect blood pressure during dynamic exercise, epidural anaesthesia must block the pressor response to post‐exercise ischaemia. The implication of these data is that complete or almost complete block of group III and/or group IV muscle afferents is necessary to inhibit the pressor response to dynamic exercise in man.

Original languageEnglish (US)
Pages (from-to)681-691
Number of pages11
JournalThe Journal of Physiology
Issue number1
StatePublished - Oct 1 1993

ASJC Scopus subject areas

  • Physiology


Dive into the research topics of 'The effect of epidural anaesthesia with 1% lidocaine on the pressor response to dynamic exercise in man.'. Together they form a unique fingerprint.

Cite this