TY - JOUR
T1 - The diffuse infiltrative lymphocytosis syndrome
T2 - Clinical and immunogenetic features in 35 patients
AU - Kazi, Salahuddin
AU - Cohen, Philip R.
AU - Williams, Francis
AU - Schempp, Rosemary
AU - Reveille, John D.
PY - 1996
Y1 - 1996
N2 - Objective: To study the epidemiological, clinical, serological and immunogenetic features of the diffuse infiltrative lymphocytosis syndrome (DILS). Design: Consecutive series of 35 patients with DILS diagnosed from 1992 to 1995 in a cohort of 4100 outpatients infected with HIV-1. Methods: Thirty-five individuals with DILS were ascertained from this cohort and followed for 720 patient-months. Clinical, serological and immunogenetic features of these patients were studied and their demographics were compared with the rest of the outpatient population. Results: DILS was found to be more prevalent in African Americans (60%) than in Caucasians (26%) or Mexican Americans (14%) [odds ratio (OR), 2.32; 95% confidence interval (CI), 1.12-4.81; P = 0.02] and in persons with male-to-male transmission of HIV-1 (71%) (OR, 2.82; 95% CI, 1.29-6.29; P = 0.007). All patients had bilateral parotid gland enlargement. The majority had sicca symptoms. The most common extraglandular sites of disease were lung (31%), muscle (26%), and liver (23%). Four patients had biopsy-proven polymyositis. Thirteen patients met the 1993 Centers for Disease Control and Prevention case definition of AIDS. Sixteen (52%) patients expressed human leukocyte antigen (HLA)-DR5 (DRB1(*)1102), DR6 (DRB1(*)1301,(*)1302), or DR7, and 11 (36%) expressed HLA-DR2. Conclusions: DILS is more common in African Americans and in persons with male-to-male transmission of HIV-1. HIV-associated polymyositis appears to occur in the setting of DILS.
AB - Objective: To study the epidemiological, clinical, serological and immunogenetic features of the diffuse infiltrative lymphocytosis syndrome (DILS). Design: Consecutive series of 35 patients with DILS diagnosed from 1992 to 1995 in a cohort of 4100 outpatients infected with HIV-1. Methods: Thirty-five individuals with DILS were ascertained from this cohort and followed for 720 patient-months. Clinical, serological and immunogenetic features of these patients were studied and their demographics were compared with the rest of the outpatient population. Results: DILS was found to be more prevalent in African Americans (60%) than in Caucasians (26%) or Mexican Americans (14%) [odds ratio (OR), 2.32; 95% confidence interval (CI), 1.12-4.81; P = 0.02] and in persons with male-to-male transmission of HIV-1 (71%) (OR, 2.82; 95% CI, 1.29-6.29; P = 0.007). All patients had bilateral parotid gland enlargement. The majority had sicca symptoms. The most common extraglandular sites of disease were lung (31%), muscle (26%), and liver (23%). Four patients had biopsy-proven polymyositis. Thirteen patients met the 1993 Centers for Disease Control and Prevention case definition of AIDS. Sixteen (52%) patients expressed human leukocyte antigen (HLA)-DR5 (DRB1(*)1102), DR6 (DRB1(*)1301,(*)1302), or DR7, and 11 (36%) expressed HLA-DR2. Conclusions: DILS is more common in African Americans and in persons with male-to-male transmission of HIV-1. HIV-associated polymyositis appears to occur in the setting of DILS.
KW - Autoimmunity
KW - CD8
KW - Disease progression
KW - Human leukocyte antigen
KW - Myopathy
KW - Salivary gland
KW - Sicca
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U2 - 10.1097/00002030-199604000-00006
DO - 10.1097/00002030-199604000-00006
M3 - Article
C2 - 8728042
AN - SCOPUS:0029942514
SN - 0269-9370
VL - 10
SP - 385
EP - 391
JO - AIDS
JF - AIDS
IS - 4
ER -