The developmental origins of adipose tissue

Daniel C. Berry, Drew Stenesen, Daniel Zeve, Jonathan M. Graff

Research output: Contribution to journalReview articlepeer-review

217 Scopus citations


Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.

Original languageEnglish (US)
Pages (from-to)3939-3949
Number of pages11
JournalDevelopment (Cambridge)
Issue number19
StatePublished - Oct 1 2013


  • Adipocyte
  • Adipose
  • Development
  • Niche
  • Stem cells
  • Vascular niche

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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