The development of the clearance concept

Donald W. Seldin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The clearance concept is central to three critical areas of nephrology; it was a key feature to early conceptual analysis of the nature of urine formation, it was utilized as a measure of kidney function in advancing renal diseases, and it was a pivotal concept to elucidate the physiology of the kidneys. This paper describes the clearance concept as currently understood and then it examines how clearance was utilized to understand these various aspects of kidney function.

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalJournal of Nephrology
Issue number1
StatePublished - Jan 1 2004


  • Carl Ludwig
  • Clearance concept
  • Hans Driesch
  • Johannes Muller

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'The development of the clearance concept'. Together they form a unique fingerprint.

Cite this