TY - JOUR
T1 - The contribution of αβ-tubulin curvature to microtubule dynamics
AU - Brouhard, Gary J.
AU - Rice, Luke M.
N1 - Publisher Copyright:
© 2014 Brouhard and Rice.
PY - 2014
Y1 - 2014
N2 - Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control the architecture of microtubule networks, microtubuleassociated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, and the transitions between these states. Recent evidence shows that many MAPs exert their effects by selectively binding to distinct conformations of polymerized or unpolymerized αβ-tubulin. The ability of αβ-tubulin to adopt distinct conformations contributes to the intrinsic polymerization dynamics of microtubules. αβ-Tubulin conformation is a fundamental property that MAPs monitor and control to build proper microtubule networks.
AB - Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control the architecture of microtubule networks, microtubuleassociated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, and the transitions between these states. Recent evidence shows that many MAPs exert their effects by selectively binding to distinct conformations of polymerized or unpolymerized αβ-tubulin. The ability of αβ-tubulin to adopt distinct conformations contributes to the intrinsic polymerization dynamics of microtubules. αβ-Tubulin conformation is a fundamental property that MAPs monitor and control to build proper microtubule networks.
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U2 - 10.1083/jcb.201407095
DO - 10.1083/jcb.201407095
M3 - Article
C2 - 25385183
AN - SCOPUS:84918514058
SN - 0021-9525
VL - 207
SP - 323
EP - 334
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 3
ER -