The collaborative work of droplet assembly

Xiao Chen, Joel M. Goodman

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

Original languageEnglish (US)
Pages (from-to)1205-1211
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number10
StatePublished - Oct 2017


  • FIT2
  • Lipodystrophy
  • Perilipin
  • Pet10
  • Seipin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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