The collaborative work of droplet assembly

Xiao Chen; Joel M. Goodman

doi:10.1016/j.bbalip.2017.07.003

The collaborative work of droplet assembly

Xiao Chen, Joel M. Goodman

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

Original language	English (US)
Pages (from-to)	1205-1211
Number of pages	7
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1862
Issue number	10
DOIs	https://doi.org/10.1016/j.bbalip.2017.07.003
State	Published - Oct 2017

Keywords

FIT2
Lipodystrophy
Perilipin
Pet10
Seipin

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.bbalip.2017.07.003

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title = "The collaborative work of droplet assembly",

abstract = "Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.",

keywords = "FIT2, Lipodystrophy, Perilipin, Pet10, Seipin",

author = "Xiao Chen and Goodman, {Joel M.}",

note = "Funding Information: This research was supported by NIH grant GM084210 and The American Heart Association Grant-in-Aid 27540010. We are grateful for discussion with other members of the Goodman lab. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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AU - Chen, Xiao

AU - Goodman, Joel M.

N1 - Funding Information: This research was supported by NIH grant GM084210 and The American Heart Association Grant-in-Aid 27540010. We are grateful for discussion with other members of the Goodman lab. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/10

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N2 - Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

AB - Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.

KW - FIT2

KW - Lipodystrophy

KW - Perilipin

KW - Pet10

KW - Seipin

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DO - 10.1016/j.bbalip.2017.07.003

M3 - Review article

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SN - 1388-1981

VL - 1862

SP - 1205

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JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 10

ER -

The collaborative work of droplet assembly

Abstract

Keywords

ASJC Scopus subject areas

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