The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism

Medicine & Life Sciences

• 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone 100%
• Mitogen-Activated Protein Kinase Kinases 57%
• Neuroprotection 55%
• Animal Models 37%
• In Vitro Techniques 23%
• Neurons 17%
• NF-kappa B 10%
• Neuroprotective Agents 9%
• farnesylthiosalicylic acid 8%
• Apoptosis 8%
• 2-oxindole 8%
• Potassium 8%
• Cell Death 7%
• Synthetic Drugs 6%
• U 0126 5%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 5%
• Huntington Disease 5%
• MAP Kinase Signaling System 5%
• Glutathione 4%
• Pharmaceutical Preparations 3%
• Phosphotransferases 3%
• Oxidative Stress 3%
• Aptitude 3%
• Therapeutics 3%
• Pathology 3%

Chemical Compounds

• Neuroprotective 66%
• Neurotoxic 44%
• Cell Death 37%
• U0126 33%
• Drug 27%
• Methylmercury(.) 22%
• Oxidative Stress 17%
• Glutathione 15%
• Block Like Crystal 11%
• Acid 6%