TY - JOUR
T1 - The Beclin 1 interactome
AU - He, Congcong
AU - Levine, Beth
N1 - Funding Information:
The work in the authors’ own laboratory was supported by NIH grants ROI AI151267 , ROI CA84254 , and ROI CA109618 to B.L. The authors thank Angela Diehl for expert medical illustration. We apologize to those authors whose work could not be cited due to space limitations.
PY - 2010/4
Y1 - 2010/4
N2 - The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases. In recent years, major advances have been made in identifying components of functionally distinct Beclin 1/class III phosphatidylinositol 3-kinase complexes, in characterizing the molecular regulation of interactions between Beclin 1 and the autophagy inhibitors, Bcl-2/BcL-XL, and in uncovering a role for viral antagonists of Beclin 1 in viral pathogenesis. The rapidly growing list of components of the 'Beclin 1 interactome' supports a model in which autophagy, and potentially other membrane trafficking functions of Beclin 1, are governed by differential interactions with different binding partners in different physiological or pathophysiological contexts.
AB - The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases. In recent years, major advances have been made in identifying components of functionally distinct Beclin 1/class III phosphatidylinositol 3-kinase complexes, in characterizing the molecular regulation of interactions between Beclin 1 and the autophagy inhibitors, Bcl-2/BcL-XL, and in uncovering a role for viral antagonists of Beclin 1 in viral pathogenesis. The rapidly growing list of components of the 'Beclin 1 interactome' supports a model in which autophagy, and potentially other membrane trafficking functions of Beclin 1, are governed by differential interactions with different binding partners in different physiological or pathophysiological contexts.
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U2 - 10.1016/j.ceb.2010.01.001
DO - 10.1016/j.ceb.2010.01.001
M3 - Review article
C2 - 20097051
AN - SCOPUS:77951237303
SN - 0955-0674
VL - 22
SP - 140
EP - 149
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 2
ER -