TY - JOUR
T1 - The basic science of vascular biology
T2 - Implications for the practicing surgeon
AU - Glotzbach, Jason P.
AU - Levi, Benjamin
AU - Wong, Victor W.
AU - Longaker, Michael T.
AU - Gurtner, Geoffrey C.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/11
Y1 - 2010/11
N2 - SUMMARY:: A thorough understanding of vascular biology will assist the reconstructive surgeon in both operative planning and development of novel surgical approaches to treat chronic wounds and tissue loss, and to optimize regenerative strategies for tissue reconstruction. In this review, several fundamental concepts of the basic science of vascular biology are discussed, with specific emphasis on the clinical implications most relevant to the reconstructive surgeon. Topics include the vascular physiology of tissue flaps and grafts, the principles of neovascularization including angiogenesis and vasculogenesis, and the basic concepts of bioengineering of vascularized tissue constructs for use in reconstruction. As basic science research increases our collective understanding of vascular physiology-specifically, in the areas of neovascularization and tissue engineering-reconstructive surgeons will be able to improve treatment of the sequelae of ischemic injuries, tissue loss, and chronic wounds.
AB - SUMMARY:: A thorough understanding of vascular biology will assist the reconstructive surgeon in both operative planning and development of novel surgical approaches to treat chronic wounds and tissue loss, and to optimize regenerative strategies for tissue reconstruction. In this review, several fundamental concepts of the basic science of vascular biology are discussed, with specific emphasis on the clinical implications most relevant to the reconstructive surgeon. Topics include the vascular physiology of tissue flaps and grafts, the principles of neovascularization including angiogenesis and vasculogenesis, and the basic concepts of bioengineering of vascularized tissue constructs for use in reconstruction. As basic science research increases our collective understanding of vascular physiology-specifically, in the areas of neovascularization and tissue engineering-reconstructive surgeons will be able to improve treatment of the sequelae of ischemic injuries, tissue loss, and chronic wounds.
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UR - http://www.scopus.com/inward/citedby.url?scp=78650143348&partnerID=8YFLogxK
U2 - 10.1097/PRS.0b013e3181ef8ccf
DO - 10.1097/PRS.0b013e3181ef8ccf
M3 - Review article
C2 - 21042110
AN - SCOPUS:78650143348
SN - 0032-1052
VL - 126
SP - 1528
EP - 1538
JO - Plastic and reconstructive surgery
JF - Plastic and reconstructive surgery
IS - 5
ER -