The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Derek J. Erstad; Andrew M. Tager; Yujin Hoshida; Bryan C. Fuchs

doi:10.1080/23723556.2017.1311827

The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.

Original language	English (US)
Article number	e1311827
Journal	Molecular and Cellular Oncology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2017.1311827
State	Published - May 4 2017
Externally published	Yes

Keywords

ATX
HCC
LPA
LPAR1
NASH
chemoprevention
cirrhosis
fibrosis
hepatocellular carcinoma
non-alcoholic steatohepatitis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2017.1311827

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title = "The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer",

abstract = "Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.",

keywords = "ATX, HCC, LPA, LPAR1, NASH, chemoprevention, cirrhosis, fibrosis, hepatocellular carcinoma, non-alcoholic steatohepatitis",

author = "Erstad, {Derek J.} and Tager, {Andrew M.} and Yujin Hoshida and Fuchs, {Bryan C.}",

note = "Publisher Copyright: {\textcopyright} 2017, {\textcopyright} 2017 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2017, {\textcopyright} Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, and Bryan C. Fuchs.",

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AU - Tager, Andrew M.

AU - Hoshida, Yujin

AU - Fuchs, Bryan C.

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Y1 - 2017/5/4

N2 - Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.

AB - Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.

KW - ATX

KW - HCC

KW - LPA

KW - LPAR1

KW - NASH

KW - chemoprevention

KW - cirrhosis

KW - fibrosis

KW - hepatocellular carcinoma

KW - non-alcoholic steatohepatitis

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The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Abstract

Keywords

ASJC Scopus subject areas

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