The Alcohol Withdrawal Syndrome. Neurobiology of Treatment and Toxicity

B. Adinoff

doi:10.1111/j.1521-0391.1994.tb00244.x

The Alcohol Withdrawal Syndrome. Neurobiology of Treatment and Toxicity

B. Adinoff

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Our increasing understanding of the neurobiology of the alcohol withdrawal syndrome has been accompanied by its safe and efficacious treatment. In this review, the biologic alterations that are associated with the signs and symptoms of withdrawal, and their relationship to current pharmacologic treatments, will be discussed. Potential long‐term neurotoxic effects of alcohol withdrawal will also be reviewed. The role of the GABA_A‐benzodiazepine receptor complex, the N‐methyl‐D‐aspartate (NMDA) receptor, the sympathetic nervous system, the hypothalamic‐pituitary‐adrenal axis, and limbic neuronal sensitization in the acute changes and persistent consequences of alcohol withdrawal will be the focus of this discussion. Potential treatment strategies based on these neurobiologic changes will be proposed. (American Journal on Addictions 1994; 3:277–288) 1994 American Academy of Addiction Psychiatry

Original language	English (US)
Pages (from-to)	277-288
Number of pages	12
Journal	The American Journal on Addictions
Volume	3
Issue number	4
DOIs	https://doi.org/10.1111/j.1521-0391.1994.tb00244.x
State	Published - 1994

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Psychiatry and Mental health

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10.1111/j.1521-0391.1994.tb00244.x

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AB - Our increasing understanding of the neurobiology of the alcohol withdrawal syndrome has been accompanied by its safe and efficacious treatment. In this review, the biologic alterations that are associated with the signs and symptoms of withdrawal, and their relationship to current pharmacologic treatments, will be discussed. Potential long‐term neurotoxic effects of alcohol withdrawal will also be reviewed. The role of the GABAA‐benzodiazepine receptor complex, the N‐methyl‐D‐aspartate (NMDA) receptor, the sympathetic nervous system, the hypothalamic‐pituitary‐adrenal axis, and limbic neuronal sensitization in the acute changes and persistent consequences of alcohol withdrawal will be the focus of this discussion. Potential treatment strategies based on these neurobiologic changes will be proposed. (American Journal on Addictions 1994; 3:277–288) 1994 American Academy of Addiction Psychiatry

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The Alcohol Withdrawal Syndrome. Neurobiology of Treatment and Toxicity

Abstract

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