The aging kidney

Xin J. Zhou; Dinesh Rakheja; Xueqing Yu; Ramesh Saxena; Nosratola D. Vaziri; Fred G. Silva

doi:10.1038/ki.2008.319

The aging kidney

Xin J. Zhou, Dinesh Rakheja, Xueqing Yu, Ramesh Saxena, Nosratola D. Vaziri, Fred G. Silva

Research output: Contribution to journal › Review article › peer-review

299 Scopus citations

Abstract

Renal aging, by itself, is associated with alterations in renal morphology and a decline in renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus and hypertension. The aging-related renal insufficiency has important implications with regards to body homeostasis, drug toxicity, and renal transplantation. An understanding of renal aging and its distinction from renal insufficiency secondary to diseases is essential for individualized care of the elderly. Toward this end, investigations are underway to elucidate the molecular mechanisms of renal aging. This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process.

Original language	English (US)
Pages (from-to)	710-720
Number of pages	11
Journal	Kidney international
Volume	74
Issue number	6
DOIs	https://doi.org/10.1038/ki.2008.319
State	Published - Sep 2008

Keywords

Kidney transplantation
Molecular mechanism
Oxidative stress
Pathology
Pathophysiology
Senescence

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2008.319

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abstract = "Renal aging, by itself, is associated with alterations in renal morphology and a decline in renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus and hypertension. The aging-related renal insufficiency has important implications with regards to body homeostasis, drug toxicity, and renal transplantation. An understanding of renal aging and its distinction from renal insufficiency secondary to diseases is essential for individualized care of the elderly. Toward this end, investigations are underway to elucidate the molecular mechanisms of renal aging. This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process.",

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AU - Zhou, Xin J.

AU - Rakheja, Dinesh

AU - Yu, Xueqing

AU - Saxena, Ramesh

AU - Vaziri, Nosratola D.

AU - Silva, Fred G.

PY - 2008/9

Y1 - 2008/9

N2 - Renal aging, by itself, is associated with alterations in renal morphology and a decline in renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus and hypertension. The aging-related renal insufficiency has important implications with regards to body homeostasis, drug toxicity, and renal transplantation. An understanding of renal aging and its distinction from renal insufficiency secondary to diseases is essential for individualized care of the elderly. Toward this end, investigations are underway to elucidate the molecular mechanisms of renal aging. This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process.

AB - Renal aging, by itself, is associated with alterations in renal morphology and a decline in renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus and hypertension. The aging-related renal insufficiency has important implications with regards to body homeostasis, drug toxicity, and renal transplantation. An understanding of renal aging and its distinction from renal insufficiency secondary to diseases is essential for individualized care of the elderly. Toward this end, investigations are underway to elucidate the molecular mechanisms of renal aging. This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process.

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KW - Molecular mechanism

KW - Oxidative stress

KW - Pathology

KW - Pathophysiology

KW - Senescence

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The aging kidney

Abstract

Keywords

ASJC Scopus subject areas

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